Modeling the collective motion of micro organism to higher perceive the formation of troublesome biofilms

Modeling the collective movement of bacteria to better understand the formation of troublesome biofilms

Graphical summary. Credit: The European Physical Journal E (2022). DOI: 10.1140/epje/s10189-022-00238-7

Biofilms kind when microorganisms corresponding to sure kinds of micro organism adhere to the floor of objects in a moist surroundings and start to breed ensuing within the excretion of a slimy glue-like substance.

These biofilms aren’t simply disagreeable and unappealing nonetheless—they are often significantly troublesome. For instance, within the medical field, the formation of biofilm can cut back the effectiveness of antibiotic remedies. The key to understanding biomass formation lies in understanding how micro organism behave en masse.

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A brand new paper in The European Physical Journal E by Heinrich-Heine-Universität, Düsseldorf, Germany, researcher Davide Breoni and his co-authors presents a mathematical mannequin for the movement of micro organism that features cell division and loss of life, the fundamental substances of the cell cycle.

The staff developed a mathematical model of bacterial motion, making a hyperlink between statistical physics and biophysics within the course of.

“Our new model belongs to a class of models for ‘active matter’ that currently encounter a lot of interest in statistical physics,” Breoni says. “This field studies the collective properties of particle systems that have their own energy source — bacteria are an exemplary case.”

The mannequin devised by the staff delivered a shock by suggesting that on the subject of motion micro organism can act as a unit.

“In the course of our investigation, we found out that the model predicts that the formation of bacterial colonies can occur through the build-up of traveling waves, concentrated ‘packages’ of bacteria,” Breoni provides. “We did not expect this to arise from such a simple model as ours.”

He believes that the outcomes ought to be attention-grabbing to the general public who could concentrate on bacterial colonies, however not understand how they transfer in a collective method.

Breoni concludes by stating this can be a quite simple mannequin suggesting how the analysis may proceed from right here. “We could try to make the model more realistic and confront the results to experiment to test its predictions,” he says. “On the other hand, this research is very much curiosity-driven and results from intense discussions among the researchers — an approach we’d like to maintain so we can continue to surprise ourselves with our findings.”

More info:
Davide Breoni et al, A one-dimensional three-state run-and-tumble mannequin with a ‘cell cycle’, The European Physical Journal E (2022). DOI: 10.1140/epje/s10189-022-00238-7

Modeling the collective motion of micro organism to higher perceive the formation of troublesome biofilms (2022, December 28)
retrieved 28 December 2022

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