‘Detecting amino acid profile alterations in children with attention deficit hyperactivity disorder (ADHD) reveals new treatment strategies.’
“Amino acids serve a significant role in brain development and functioning. In particular, certain amino acids or their precursors are well-established to be involved in neuronal signaling as neurotransmitters. Correspondingly, disruption of amino acid metabolism results in significant neurological disorders, particularly in children”, says Anatoly Skalny, DSc, Head of RUDN Department of medical parts research.
This research includes measuring amino acids stage within the blood serum of 102 kids aged 7 to 14 years with 71 of them had been identified with ADHD and the remainder of the members had been neurotypical (with out identified issues).
The outcomes of the research present that the serum amino acid profile in kids with ADHD differs from neurotypical kids. Histidine, glutamine, and proline ranges had been decrease and aspartic acid, glutamate and hydroxyproline had been larger.
The ratio of glutamine to glutamate in kids indicating the transmission of nerve impulses and the ratio of proline to hydroxyproline, a marker of issues of collagen metabolism and connective tissue are decrease in ADHD kids.
Therefore, understanding the potential underlying mechanisms implicated in ADHD pathogenesis is important for the event of administration methods sooner or later.