Autophagy in major human diseases


Basic principles of autophagy modulation as a therapeutic strategy for human disease In multiple settings including various neurodegenerative conditions, autophagy defects contribute to disease onset and progression, suggesting that autophagy activators may mediate beneficial effects. Conversely, proficient autophagic responses support tumor progression and resistance to therapy, pointing to autophagy inhibition as an appropriate therapeutic approach. In both scenarios, the effect of autophagy modulation on non-diseased cells must be carefully considered to enable safety and superior therapeutic efficacy. Credit: DOI: 10.15252/embj.2021108863

In a consensus article, Federico Pietrocola, at the Department of Biosciences and Nutrition, KI, and colleagues explore the pathophysiological relevance of autophagy in human illnesses, while highlighting the therapeutic potential of autophagy-centered strategies in the clinic. This article represents a remarkable collective effort by the international autophagy community, serving a guide for basic and clinical scientists to get more insights on this fascinating process.

Autophagy refers to molecular pathways for the preservation of cellular and organismal homeostasis and up to now three major forms have been described.

In article ad

In the article, published in the The EMBO Journal, Federico Pietrocola, at the Department of Biosciences and Nutrition, and his team review and discuss preclinical data and link autophagy dysfunction to the pathogenesis of major human disorders, including cancer, as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

They conclude with suggesting ideas for future studies and highlighting a few general concepts that emerged, like that modulation of autophagy for therapeutic purposes remains a promising strategy for the management of multiple human disorders.

Proteomic analysis reveals when and how which proteins are degraded in cancer cells by autophagy pathways

More information:
Daniel J Klionsky et al, Autophagy in major human diseases, The EMBO Journal (2021). DOI: 10.15252/embj.2021108863

Autophagy in major human diseases (2021, September 8)
retrieved 8 September 2021

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Source link

Leave a reply

Please enter your comment!
Please enter your name here