However, latest work from Prof. Amitabha Chattopadhyay’s group on the CSIR-CCMB means that statins might induce adjustments within the structure of cells as properly, presumably resulting in the negative effects.
The cell’s structure, known as the cytoskeleton, is manufactured from proteins akin to actins, which kind polymers. They lie beneath the plasma membrane that surrounds every cell within the human physique, and assist the cells preserve their form and dimension.
Prof Chattopadhyay’s research reveals that statins might induce polymerisation of actin cytoskeleton, along with ldl cholesterol reducing.
Published in Journal of Lipid Research (by the American Society of Biochemistry and Molecular Biology), the research reveals that statins have an effect on actins on account of a number of mobile signalling pathways.
“Our results constitute one of the first comprehensive reports dissecting the mechanistic basis underlying the interplay between cellular actin level and cholesterol biosynthesis, and provide a molecular basis for the reported side effects of statin treatment,” mentioned Dr Parijat Sarkar, who’s the primary writer of the paper.
“These findings could provide vital clues in dissecting the biochemical processes that give rise to adverse effects of statins, thereby helping to develop better drugs in the future,” mentioned Prof Chattopadhyay.
Source: IANS
