“The placenta is only a temporary organ that aids in the exchange of nutrients and waste between mother and child during pregnancy, but how the placenta responds to toxicants like BPA during pregnancy can lead to long-term health consequences,” Rosenfeld stated. “We focused on the role of microRNAs within the placenta, which are known to be key mediators in regulating cellular functions, including neural development, and the identification of certain markers for cancer.”
Rosenfeld suspects the microRNAs are enjoying a task in how the consequences of BPA publicity can result in neurological issues later in life.
“These microRNAs can be packaged inside extracellular vesicles and can be transported to distant organs within the body,” Rosenfeld stated. “We’re assuming that by changing the pattern of microRNAs in the placenta, these small molecules can then reach the brain, resulting in harmful effects. Even before the brain’s neurons are developed, these microRNA packages may already be guiding fetal brain development. These changes may even be different in female versus male fetuses.”
BPA is utilized in many home goods resembling plastic water bottles and meals containers, and the epoxy coating of metallic meals cans. Exposure can happen in the course of the easy act of microwaving meals inside polycarbonate plastic meals containers. While latest efforts have begun towards making merchandise “BPA free,” the greater than decade-long debate surrounding what’s thought of secure ranges of BPA publicity continues. Numerous research have regarded into attainable associated well being penalties, together with neurobehavioral issues, diabetes, weight problems and varied reproductive deficiencies.
Rosenfeld believes microRNAs’ adjustments within the placenta is also used as an early diagnostic biomarker for BPA publicity.
“By identifying the relationship between these microRNAs and fetal brain development through BPA exposure, targeted therapies could eventually be developed to help prevent or reverse some of the harmful effects of BPA exposure that occur due to these microRNAs,” Rosenfeld stated.
Future plans for this work embrace analyzing the connection between the placenta and the mind outdoors of the physique by means of utilizing cell tradition techniques.
This newest discovery continues a greater than decade-long curiosity by Rosenfeld on the consequences of BPA publicity. Her most up-to-date deal with the connection between the placenta and the mind might assist scientists with creating a basis for an early step in translational drugs, or analysis that goals to enhance human well being by figuring out the relevance of animal science discoveries to folks.
“MiRNA changes in the mouse placenta due to bisphenol A exposure,” was printed in Epigenomics. Co-authors embrace Jiude Mao, Jessica Kinkade and Nathan Bivens at MU. Funding was supplied by a grant from the National Institute of Environmental Health Sciences (1R01ES025547). The content material is solely the duty of the authors and doesn’t essentially characterize the official views of the funding company.