Nitric oxide interacts with completely different parts of the big community of proteins and different molecules that encompass, assist, and provides construction to tumor cells and tissues within the physique. Hyaluronic acid is without doubt one of the predominant parts of this community and is the fabric of selection for fabricating these hydrogels.
“HA plays multiple roles in tumor tissues” says Amir. “However, its interactions with nitric oxide have not been thoroughly investigated. The study, recently published in Biomacromolecules, attempts to understand the mechanism of these interactions and the different effects on nitric oxide levels and migration of breast cancer cells.”
The research is supervised by Prof Abhay Pandit, Scientific Director of CRAM, and was printed with collaborators Dr Sharon Glynn from the Lambe Institute for Translational Research and Dr Pau Farras from the School of Biological and Chemical Sciences within the Ryan Institute on the National University of Ireland Galway.
The work investigated the power of HA to scavenge nitric oxide. The group discovered that the conversion of nitric oxide to sure nitrogen centered free radicals causes the HA to interrupt down, which additional inhibits the nitric oxide induced migration of most cancers cells within the tumor atmosphere.
Collectively, these outcomes assist towards understanding the involvement of HA in nitric oxide induced cell migration and suggests the potential use of modified HA, as a key materials in numerous biomedical functions.
Commenting on the research, Professor Abhay Pandit, mentioned: “While the recent progress in research about the roles of nitric oxide with tumor progression resulted ultimately in a number of ongoing clinical trials for evaluating the effects of NO-synthase inhibitors, we are focusing on NO itself trying to avoid the side effects/reactions of these inhibitors.”