This research is led by Dr. Shaojun Dong (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences). At the start of this work, researchers needed to design a easy methodology to synthesize Co nanoparticles. This is as a result of that the Co NPs are very lively for varied catalytic reactions reminiscent of dehydrogenation and hydrogenation reactions, the selective oxidation of alcohols, and Fischer–Tropsch syntheses. Encapsulation of Co NPs with porous carbon is an efficient method for stopping aggregation and leaching of Co NPs, thus enhancing their exercise and stability. “In most synthesis methods, the carbon sources are often solid materials, which need additional solvent to dissolve and re-separate. If these carbon sources can be melted and used as solvents, the synthesis steps will be greatly simplified” Shaojun says.
After experimenting with numerous totally different sorts of small natural molecules, the crew lastly discovered that imidazole has a low melting level and excessive solubility for cobalt ions, which may be very appropriate for the synthesis of carbon supported cobalt nanoparticles. The complete synthesis course of solely wants two steps. The porous construction of the synthesized materials is evenly distributed with numerous cobalt nanoparticles on the floor. “We were shocked by the first SEM image of the material. This is beyond our expectation,” Jinxing says.
The crew discovered that the multi-dimensional carbon supported Co nanoparticles (Co/C) catalyst simulating the operate of pure NADH oxidase. The Co/C nanoparticles can eat NADH in cancer cells, induce the rise of reactive oxygen species, result in the injury of oxidative phosphorylation and the lower of mitochondrial membrane potential, and result in the injury of ATP manufacturing.
Jinxing Chen et al, Bubble-templated synthesis of nanocatalyst Co/C as NADH oxidase mimic, National Science Review (2021). DOI: 10.1093/nsr/nwab186
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Melted imidazole as solvent to manufacture a porous carbon supported catalyst (2021, December 28)
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