Possible Reason for the Failure of Immunotherapy in Glioblastoma


It is seen that almost all of each main and recurrent tumors have a low density of TILs. While all of the instances of tumors have CD3+ TILs. A considerably increased CD8+ TIL density was demonstrated by quantitative evaluation of TILs at recurrence.

Moreover, between main and recurrent teams, there was no distinction noticed in CD3+, CD4+ and PD-1+ TIL density. Treatment goal like anti-PD-1 antibodies with immune checkpoint inhibition, blocks PD-1/PD-L1 interactions. This restores the effector T cell proliferation and performance.

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Immunotherapy in Glioblastoma

In a particular kind of most cancers – melanoma, it was seen that response to anti-PD-1 immunotherapy is related to the next density of CD8+ TILs. However, earlier medical trials which were carried out utilizing anti-PD-1 immunotherapy in glioblastoma, demonstrated restricted success.

Studies just like the CheckMate 143 trial and related ones demonstrated no important general survival profit in recurrent glioblastoma with anti-PD-1 when in comparison with the anti-angiogenic drug bevacizumab.

However, one other research (Cloughesy et a) states that anti-PD-1 remedy considerably will increase the general survival if given earlier than and after recurrent tumor resection than solely after recurrent surgical procedure.

“The level of T cell infiltration seen in this small cohort of matched primary and recurrent glioblastoma tissue was low. Though the number of CD8+ TILs was significantly higher in recurrent compared to primary tumours, overall TIL density at recurrence was still mild. PD-1+ TILs in particular were absent in the majority of our cases. Whether this is why many clinical trials using anti-PD-1 immunotherapy have not shown significant survival benefit in glioblastoma requires further investigation,” say the Tooney Research Team.

Source: Medindia

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