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Safety of COVID-19 mRNA Vaccines for Heart Failure Patients

“Our results indicate that heart failure patients should be prioritized for COVID-19 vaccinations and boosters,” stated research creator Dr. Caroline Sindet-Pedersen of Herlev and Gentofe Hospital, Hellerup, Denmark.

“COVID-19 vaccines will continue to be important for preventing morbidity and mortality in vulnerable patient populations. Thus, studies emphasizing the safety of these vaccines are essential to reassure those who might be hesitant and ensure continued uptake of vaccinations.”


Patients with coronary heart failure are at elevated threat of hospitalization, want for mechanical air flow, and demise attributable to COVID-19. Vaccination reduces the danger of great sickness from COVID-19. However, “Due to perceptions about possible cardiovascular side effects from mRNA vaccines in heart failure patients, this study examined the risk of cardiovascular complications and death associated with mRNA vaccines in a nationwide cohort of patients with heart failure,” stated Dr. Sindet-Pedersen.

The research included 50,893 unvaccinated sufferers with coronary heart failure in 2019 and 50,893 sufferers with coronary heart failure in 2021 who had been vaccinated with both of the 2 mRNA vaccines (BNT162B2 or mRNA-1273). The two teams had been matched for age, intercourse, and period of coronary heart failure. The median age of individuals was 74 years and 35% had been ladies. The median period of coronary heart failure was 4.1 years. Participants had been adopted for 90 days for all-cause mortality, worsening coronary heart failure, venous thromboembolism, and myocarditis, ranging from the date of the second vaccination for the 2021 group and the identical date in 2019 for the unvaccinated group.

The researchers in contrast the danger of opposed outcomes within the two teams, after standardizing for age, intercourse, coronary heart failure period, use of coronary heart failure drugs, ischemic coronary heart illness, most cancers, diabetes, atrial fibrillation, and admission with coronary heart failure lower than 90 days earlier than the primary date of comply with up. Dr. Sindet-Pedersen defined: “Standardization imitates a randomized trial and is a way to obtain a better causal interpretation of the results from observational studies.”

Is COVID-19 mRNA Vaccine Safe for Heart Patients?

Among 101,786 coronary heart failure sufferers, the researchers discovered that receiving an mRNA vaccine was not related to an elevated threat of worsening coronary heart failure, myocarditis or venous thromboembolism however was related to a decreased threat of all-cause mortality.

The standardized threat of all-cause mortality inside 90 days was 2.2% within the 2021 cohort (vaccinated) and a couple of.6% within the 2019 cohort (not vaccinated), displaying a considerably decrease threat for all-cause mortality in 2021 versus 2019. The standardized threat of worsening coronary heart failure inside 90 days was 1.1% in each cohorts. Similarly, no vital variations had been discovered between teams for venous thromboembolism or myocarditis.

Dr. Sindet-Pedersen concluded: “The study suggests that there should be no concern about cardiovascular side effects from mRNA vaccines in heart failure patients. In addition, the results point to a beneficial effect of vaccination on mortality.”


1. COVID mRNA vaccines are secure in sufferers with coronary heart failure – (https://www.escardio.org/The-ESC/Press-Office/Press-releases/COVID-mRNA-vaccines-are-safe-in-patients-with-heart-failure)

Source: Eurekalert

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