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Study Shows How Bacteria Makes Copper into Antibiotic

Fluopsin C was found in 1970. It is a broad-spectrum antibiotic that kills a variety of micro organism and fungi, together with strains proof against different medicine.

Electron paramagnetic resonance

Li’s group at UNC adopted the uptake of copper by cultured P. aeruginosa and confirmed that the copper atoms had been included into fluopsin C.

They labored with Lizhi Tao, postdoctoral fellow in Professor David Britt’s lab on the UC Davis Department of Chemistry, utilizing electron paramagnetic resonance, or EPR, to review the artificial pathway. The researchers discovered that two small sulfur-containing molecules bind to every copper atom in a mixture of cis and trans isomers.

The examine exhibits how Fluopsin C may very well be synthesized by an enzymatic course of as a substitute of utilizing hazardous chemical compounds. Repurposing copper into an antibiotic on this approach is a distinct response from processes in most organisms, which both sequester or export the steel from the cell, Li mentioned.

EPR is a type of magnetic resonance spectroscopy which is especially suited to learning metals in natural molecules. Britt’s lab at UC Davis operates the CalEPR heart, with seven EPR devices, the biggest facility of its form on the West coast.

Additional authors on the paper are Jon Patteson, Andrew Putz, William Simke and Henry Bryant III, all at UNC. The work was supported by grants from the NIH and a Packard Fellowship to Li.

Source: Eurekalert

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