Trial Into Antioxidant for Parkinson’s Disease Yields Disappointing Results


By Cara MurezHealthDay Reporter

FRIDAY, Sept. 17, 2021 (HealthDay News) – Researchers hoped to point out that the pure antioxidant urate might delay Parkinson’s disease development, however a examine accomplished at Massachusetts General Hospital dashed these expectations.

The trial enrolled almost 300 people not too long ago recognized with early Parkinson’s illness, which impacts the physique’s motor system. Symptoms akin to tremors, stiff limbs and stability issues progress steadily, and there’s no identified remedy.

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The analysis crew discovered no important distinction within the price of illness development for these given the metabolite inosine for 2 years in comparison with the placebo group.

Inosine raises ranges of urate within the brain and blood. It has appeared neuroprotective in preclinical fashions.

The inosine didn’t show helpful, and those that obtained it additionally had an elevated price of kidney stones, in response to the examine.

“The convergence of epidemiological, biological and clinical data from past research made a compelling argument that elevating urate, the main antioxidant circulating in the blood, could protect against the oxidative damage thought to play a role in Parkinson’s disease,” mentioned senior writer Dr. Michael Schwarzschild, a neurologist at Mass General and a professor of neurology at Harvard Medical School.

“While our study did not rule out a protective effect of urate in Parkinson’s, it clearly showed that increasing urate did not slow disease progression based on clinical assessments and serial bran scan,” he added in a hospital information launch.

Though it did not present solutions to illness development, Schwarzschild mentioned the examine was profitable in different methods.

“The findings were very helpful in providing a reality check that now allows the field to move on to other therapeutic approaches,” mentioned Schwarzschild. “We also learned a lot in terms of clinical trials science for Parkinson’s, and ways to conduct future studies that will increase their chance of success.”

The findings had been printed Sept. 14 within the Journal of the American Medical Association.

More data

The Parkinson’s Foundation has extra on Parkinson’s disease.

SOURCE: Massachusetts General Hospital-Harvard University, information launch, Sept. 14, 2021

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